GYNOSTEMMA PENTAPHYLLUM 5:1 EXTRACT (JIAGULAN) (STEM AND LEAVES)

Gynostemma pentaphyllum, commonly known as Jiagulan, is a perennial vine native to Southern China, often referred to as the "herb of immortality" due to its traditional use in promoting longevity and well-being. This 5:1 extract, derived from the stems and leaves, concentrates the plant's beneficial compounds, providing a potent ingredient for dietary supplements. Historically, Jiagulan has been consumed as a tea for centuries, valued in traditional Chinese medicine (TCM) for its adaptogenic properties and wide range of health-supporting effects. Its growing recognition in modern nutraceuticals stems from its rich phytochemical profile, which includes a unique class of triterpenoid saponins known as gypenosides. These compounds are structurally similar to ginsenosides found in Panax ginseng, leading to Jiagulan sometimes being called "southern ginseng." The careful extraction process ensures a standardized potency, capturing the essence of this remarkable botanical for optimal efficacy in various formulations.

The primary active compounds responsible for Jiagulan's extensive health benefits are the gypenosides, of which over 100 distinct types have been identified. These saponins exert their effects through multiple biochemical pathways. As a potent adaptogen, Gynostemma pentaphyllum helps the body adapt to various stressors, modulating the hypothalamic-pituitary-adrenal (HPA) axis and supporting physiological balance, as evidenced by studies on stress response in animal models. Furthermore, gypenosides are recognized for their robust antioxidant activity, enhancing endogenous antioxidant enzymes like superoxide dismutase (SOD), catalase, and glutathione peroxidase, thereby mitigating oxidative stress at a cellular level. Research also indicates its role in metabolic health, with studies suggesting gypenosides can activate AMP-activated protein kinase (AMPK), a crucial enzyme involved in energy homeostasis, which may contribute to improved lipid and glucose metabolism, supporting healthy blood sugar and cholesterol levels.

Gynostemma pentaphyllum 5:1 extract is highly versatile for supplement formulations, commonly incorporated into capsules, tablets, and powdered blends designed for energy, stress relief, cardiovascular support, and metabolic wellness. Its adaptogenic qualities make it an excellent candidate for synergistic combinations with other adaptogens like Rhodiola rosea or Ashwagandha. To ensure maximum efficacy and safety, sourcing high-quality raw materials and employing precise extraction methods are paramount. Scientific research continues to explore the full spectrum of Jiagulan's benefits, with human clinical trials demonstrating its potential to support cardiovascular function by promoting healthy blood pressure and improving endothelial function through nitric oxide synthesis, as reported in various peer-reviewed journals. Further studies highlight its hepatoprotective effects and potential to enhance physical endurance, underscoring its broad therapeutic applicability and reinforcing its traditional reputation as a valuable health tonic.